It
was thought that only pluripotent stem cells could give rise to all
types of cells in the body, until now.
Embryonic stem
cells have triggered controversy, with objections from the Roman
Catholic Church, which says that an embryo is a human life.
In 2007, "induced"
pluripotent stem cells were created to help ease moral
objections.
These are adult
skin cells that are reprogrammed with a basket of genes and bath of
proteins back to their pluripotent state, and then prompted into
developing into a new cell type.
This new research
skips this intermediary stage by converting mature cells, taken
from the skin of mice tails, into neurons in a lab dish all in a
single step.
Thomas Vierbuchen,
who led the study, used three genes involved in reprogramming and
neutral function.
It took less than a
week for the transformation, after which the cells were injected
into living mice. The former skin cells looked like brain
cells and expressed neural proteins.